The same chemical compound can exist in different solid forms like crystals, solvates, desolvated solvates or amorphous solids. The diverse polymorphic forms exhibit different physical properties, such as solubility, melting point, particle size, dissolution rate and hygroscopicity, which are relevant to the bioavailability of the compounds. Therefore, the differentiation and characterization of polymorphs becomes more and more routine for pharmaceutical companies. The unique Bruker FM technology offers the measurement of the complete FIR-MIR spectral range in one step and allows for simultaneous identification and polymorph screening of samples.
Spectra of different antibiotic sulfathiazole polymorphs.
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